Mapping Myeloarchitecture using T2* and Magnetization Transfer

Data Acquisition

7T MRI at the Harvard Martinos Center for Biomedical Imaging (Boston)

Example of data:

Data Processing

Correct artifacts and process T2*:

Use FreeSurfer to reconstruct the surface:

Map T2* values into the cortex of each individual and register to human surface template:

Use Multimodal Information to Study Neuronal Architecture

Reproducibility of T2* mapping and distribution across Brodmann areas:

Multimodal mapping:

Study the Effect of Tissue Orientation With Respect to B0

Map the orientation of the cortical surface with respect to B0:

Results show an orientation dependence only in regions with high degree of myelination!


  • Cohen-Adad J. What can we learn from T2* maps of the cortex? Neuroimage 2013. j.neuroimage.2013.01.023

  • Cohen-Adad J, Polimeni JR, Helmer KG, Benner T, McNab JA, Wald LL, Rosen B, Mainero C. T2* mapping and B0 orientation-dependence at 7T reveal cyto- and myeloarchitecture organization of the human cortex. Neuroimage 2012;DOI: 10.1016/j.neuroimage.2012.01.053. PDF